Immanuel Freedman

Profile

Imaging, Modeling and Simulation
  • Imaging, Modeling & Simulation
  • Systems, Signals & Algorithms
  • Data Science

942 Clubhouse Drive
Harleysville, PA 19438
215-527-1779 (ph)


Dr. Immanuel Freedman


Qualifications

 Ph.D. Physics, B.Sc. (Honors) Physics, CPhys, MInstP, SMIEEE

License: USPTO # 51,704.


Technical Background 

Developed wavelet-based system for remote surveillance effective over ADSL lines. Completed viability study for Board of large European telecom. Enabled MPEG interactive television and mobile videophone commerce solutions for iSeeTV.  Developed interactive television set top box firmware.  Developed screen scrape software for FannieMae MORNET Loss Mitigation System.

Developed attitude determination, calibration  and sensor processing systems for  LANDSAT, SPOT and COBE satellites; developed firmware for  Cyrax 3D and software for Laser-Scan 2D laser-scanning Geographic Information Systems.

Integrated  knowledge using pharmacometrics and quantitative systems pharmacology to design and report clinical trials and pre-clinical studies by translating exposure-response relationships across diseases, phases and species.

Analyzed mathematical models related to Babylonian astronomy applying linguistics and Assyriology to translate cuneiform texts.

Selected  Cases

Retained by Finnegan, Henderson, Farabow, Garrett & Dunner LLP as Expert Witness for respondent LGE and Steptoe & Johnson LLP as Expert Witness for respondent Mitsubishi in a television program guide patent lawsuit at the United States International Trade Commission.  Matter settled before trial.
 
Retained by Drinker Biddle & Reath LLP as Expert Witness for the respondent Pioneer in a Blu-ray Disc Player patent  lawsuit at the United States International Trade Commission. Matter settled before trial.
 
Retained by Weil, Gotshal & Manges LLP as Expert Witness for the defendants (and counterclaim plaintiffs) in the ACTV, Inc. & HyperTV, Inc. v. The Walt Disney Co., ABC, Inc. and ESPN, Inc. interactive television patent lawsuit. Case closed.
 
Retained by the Office of the Chief Counsel, IRS as Expert Witness on video technology and special effects  in a Research Tax Credit case.  Case closed.

Retained by Freitas, Angell & Weinberg LLP as Expert Witness on continuous recording devices in the Dragon v. A.T & T patent lawsuit. Case closed.

Retained by State of North Carolina on behalf of the United States Attorney General's investigation into promotional practices related to blood thinner medicine.   Engagement complete.

Retained on behalf of a confidential client for several Inter Partes Review cases related to High Efficiency Video Coding (H.265)

Selected  Publications & Invited Talks

  Imaging Science

"Video Compression," in The Handbook of Computer Networks (Hossein Bidgoli, ed.), pub:John Wiley & Sons, Inc.

"Video," in The Encyclopedia of Human-Computer Interaction (William Sims Bainbridge, ed.), pub:Berkshire Publishing Group, LLC.

"Video Compression," in The Internet Encyclopedia (Hossein Bidgoli, ed.), pub:John Wiley & Sons, Inc.

Pharmacometrics

Wilkins, J.  et al. (2019), ISoP Position Statement on “Guidance Document: Population Pharmacokinetics: July 2019”, Docket No. FDA 2019-D-2398

Freedman, I. (2019), "Chaos Synchronization: Identifying & Predicting Noisy Complex Systems," invited speaker & moderator in AAPS Forum to Connect Predictive Modelers, May 6-7, 2019 Boston MA

Pillai, N. et al. (2019), "Estimating Parameters of Nonlinear Dynamic Systems in Pharmacology using Chaos Synchronization and Grid Search", JPKPD 

van Oordt, C. W. M. H et al. (2019), "ImmunoPET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" , J Nucl Med jnumed.118.214726 published ahead of print February 7, 2019

Norris, D. et al. (2018), “Expansion Cohorts: Use in First-In-Human Clinical Trials To Expedite Development of Oncology,” submitted to FDA, FDA-2018-D-2777-0001, DOI 10.17605/OSF.IO/NMGH8

Freedman, I. (2018), “IEEE Digital Health Standards,” at FIS Global , November 27, 2018, Collegeville:PA

Freedman, I. (2018), “Chaos Synchronization: Estimating Parameters of Noisy Complex Systems,” in IEEE Section Night, October 20, 2018, Philadelphia:PA

Schieke, M. & Freedman, I. (2018), “3D Topological Mapping of Macroanatomy and Microanatomy for Use in Big Data and Augmented Intelligence Systems,” in IEEE-Standard Association Workshop on Digital Health Standards, September 11, 2018, Atlanta:GA

Pillai, N. et al. (2018), "Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: estimating tumor antigenicity in a model of immunotherapy," PBMB Special Issue Volume 139, November 2018, Pages 23-30

Pillai, N. et al. (2018), "Estimating parameters of chaotic systems: chaos synchronization combined with Nelder-Mead search, " in PAGE 2018: May 31, 2018, Montreux CH

O'Connor, M. A. et al. (2017), "Elucidating Exposure-Response (Safety and Efficacy) of Adct-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Containing Antibody Drug Conjugate, for Recommended Phase 2 Dose Determination in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma," in American Society of Hematology  59th Annual Meeting & Exposition, Atlanta GA Dec 9-12, 2017

Freedman, I., Bies, R. R., Pillai, N., Schwartz, S., Ho, T. (2017), "Estimating parameters of chaotic systems in pharmacology", invited talk in American Conference on Pharmacometrics 8, Oct 14-19, 2017, Ft. Lauderdale:FL

McGeoch, A.C. et al. (2017), "ImmunoPET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" in Annual Congress of the European Association of Nuclear Medicine, Oct 21-25, 2017, Vienna:AT

"Pharmaco-Imaging in Translational Science and Research," in Pharmaco-Imaging in Drug and Biologics Development, (Brian R. Moyer, Narayan P. S. Cheruvu & Tom Hu, eds.), pub: AAPS/Springer

Nguyen, T-H-H. et al. (2016), Model evaluation of continuous data pharmacometric models: metrics and graphics, CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):87-109

Freedman, I., Bies, R.  R. & Pillai, N. (2016), "Estimating parameters of chaotic systems," invited speaker, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, November 13-17, 2016, Denver:CO

Freedman, I. (2015), “Imaging & Microdialysis: Complementary Modalities?” invited panelist, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, October 24-29, 2015, Orlando:FL

Bies, R. R., Ho, T. & Freedman, I. (2015), “Nonlinear dynamic physiological systems: Chaos Synchronization as an approach to parameter estimation” in Kinetic and Dynamic Complexity in Drug Transit-Response in the Human Body, satellite meeting to Population Approach Group Europe 2015,  June 2, 2015, Hersonissos:GR

Freedman, I. (2015), “Model Evaluation and Selection,” invited talk to American Association of Pharmaceutical Sciences Pharmacometrics Focus Group, March 26, 2015

Freedman, I., Moyer, B.R & Cheruvu, N.P.S. (2014), “Pharmaco-Imaging”, in American Association of Pharmaceutical Sciences Translational Sciences 101 e-learning course, retrieved from http://www.aaps.org/TS101/

Freedman, I. (2014), “Role of Pharmacology in Anti-Cancer Antibody Development,” invited talk, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Nov 2-6, San Diego:CA

Austin, D., Freedman, I., Grove, R, Tolson, J. & Vanmeter, S. (2014), "The Relationship Between Peripheral B-Cell Levels and MRI Disease Activity in Relapsing-Remitting Multiple Sclerosis (RRMS)", dual presentation in American Academy of Neurology 66th  Annual Meeting, Philadelphia:PA

Freedman, I. & Bies, R. (2013),"Chaos Synchronization," invited talk, in 3rd Annual Indiana Clinical and Translational Sciences Institute Symposium on Disease and Therapeutic Response Modeling, Nov 5-6, 2013, Indianapolis, IN  

Freedman, I. (2013), “Translational pharmacometric models of anti-cancer antibodies,” invited talk, in 2nd International Conference on Translational & Personalized Medicine, Aug 5-7, 2013, Chicago IL

Freedman, I. (2012), “Case Studies in the Use of Imaging Agents in Proof-of-Concept and Early Proof-of-Efficacy Trials,” invited talk, in National Biotechnology Conference, May 21-24, 2012, San Diego:CA

Freedman, I. (2012), “Regulatory Opportunities and Hurdles with Imaging Agents in the Era of Personalized Medicine,” invited panelist, in National Biotechnology Conference, May 21-24, 2012, San Diego:CA

Freedman, I. (2012), “Translating Clinical and Pre-Clinical Information into Success,” invited talk, in 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA

Freedman, I. (2012), “Improving Integration of PK/PD Modeling into the Drug Development Process,” invited panelist, in 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA

Freedman, I. (2011), “The Impact of 3D Tissue Models on Drug Development and Predictive Safety,” invited panelist, in Predictive Functional Tissue Models, November 17-18, 2011, Boston:MA

Freedman, I. (2011), “Case Study–Optimizing Design of a Phase 2 Clinical Trial in Relapsing-Remitting Multiple Sclerosis,” invited talk, in Joint Statistical Meetings 2011, Miami FL July 30-August 4, 2011

Freedman, I. (2011), “Case Study–Bridging from Western to East Asian Population in Accordance with ICH E5,” in American Conference on Pharmacometrics 2011, San Diego CA April 3-6, 2011

Freedman, I et al. (2009), “Bayesian Parametric Schild Analysis from a Whole Blood Stimulation Assay,” in American Conference on Pharmacometrics 2009, Mystic CT October 4-7, 2009

Freedman, I. (2009), “Feasibility of Immunogenicity Assessment based on Models of Polyclonal Anti-Drug Antibody Immunodynamics,” in American Conference on Pharmacometrics 2009, Mystic CT October 4-7, 2009


History of Science

Freedman. I. (2021), "Modern Methods of Chaos & Babylonian Mathematical Astronomy," Ronin Institute Public Seminar 

Freedman, I. (2021), “On mul SAG.ME.GAR,” NABU 2021-2, Nr. 52 

Freedman, I.(2018),  "The Intellectual Heritage of Babylonian Astronomy: Music of the Spheres," in Rencontre Assyriologique Internationale 64, July 14-20, 2018, Innsbruck Austria ; preprint DOI:10.13140/RG.2.2.36190.36161

Freedman, I.(2016),  "Babylonian astronomers predicted lunar and planetary positions using iterated maps, forerunners of deterministic chaos," in Rencontre Assyriologique Internationale 62, July 11-15, 2016, Philadelphia PA

Cataloluk, O. & Freedman, I. (2016), "The meaning of armannu," in Rencontre Assyriologique Internationale 62, July 11-15, 2016, Philadelphia PA

Freedman, I. (2015), "On MA.NA EN.NUN in mulAPIN," NABU 2015-2 Nr. 50

Freedman, I. (2015), “Short Note: On an Assyriological Interpretation of the Book of Daniel 5:1–28,” Journal of Translation 11(1), 74

Freedman, I. (2015), “On an Assyriological interpretation of Constantine’s labarum” retrieved from ResearchGate  DOI: 10.13140/RG.2.2.33956.76160

Freedman, I. (2015), “The Marduk Star Nēbiru,” Cuneiform Digital Library Bulletin 2015:3, retrieved from https://cdli.ucla.edu/file/publications/cdlb2015_003.pdf

Freedman, I. (2014), “On horses and bitumen in mulAPIN,” NABU 2014-1 Nr. 33