Immanuel Freedman

• Imaging, Modeling & Simulation
• Systems, Signals & Algorithms
• Data Science

942 Clubhouse Drive
Harleysville, PA 19438
215-527-1779 (ph)

Dr. Immanuel Freedman

Qualifications

Ph.D. Physics, B.Sc. (Honors) Physics, CPhys, MInstP, SMIEEE, FRSM

License: USPTO # 51,704.

Technical Background

Selected Cases

Selected Publications & Invited Talks

"Video Compression," in The Handbook of Computer Networks (Hossein Bidgoli, ed.), pub:John Wiley & Sons, Inc.

"Video," in The Encyclopedia of Human-Computer Interaction (William Sims Bainbridge, ed.), pub:Berkshire Publishing Group, LLC.

"Video Compression," in The Internet Encyclopedia (Hossein Bidgoli, ed.), pub:John Wiley & Sons, Inc.

Pharmacometrics

Freedman, I., Roepcke, S. & Li, Z. (2024), “Exposure-Response Relationships: Hyaluronidase-Facilitated Subcutaneous and Intravenous Immunoglobulin 10% in Chronic Inflammatory Demyelinating Polyradiculoneuropathy, poster in American Association of Neuromuscular & Electrodiagnostic Medicine 2024, Savannah GA

Wassermann, R. L. et al. (2024), “Assessing hyaluronidase-facilitated subcutaneous immunoglobulin 20% (fSCIG 20%) pharmacokinetics, safety and tolerability in primary immunodeficiency diseases: phase 2/3 study design, Clinical Immunology Society 2024, Minneapolis MN

Kanegane, H. et al. (2024),“ A Japanese Phase 3 Study of Subcutaneous Immunoglobulin 10% with Recombinant Human Hyaluronidase Every 3 or 4 Weeks for Primary Immunodeficiency Disease, Japanese Society for Immunodeficiency and Autoinflammatory Diseases 2024, Tokyo JPN

Freedman, I., Roepcke, S. & Li, Z (2024),“Population Pharmacokinetic Simulations in CIDP and MMN: Hyaluronidase-Facilitated Subcutaneous Immunoglobulin and Intravenous Globulin G 10% in Peripheral Nerve Society Annual Meeting 2024, Montreal Quebec CAN

Wilkins, J.  et al. (2019), ISoP Position Statement on Guidance Document: Population Pharmacokinetics: July 2019 Docket No. FDA 2019-D-2398

Freedman, I. (2019), "Chaos Synchronization: Identifying & Predicting Noisy Complex Systems," invited speaker & moderator in AAPS Forum to Connect Predictive Modelers, May 6-7, 2019 Boston MA

Pillai, N. et al. (2019), "Estimating Parameters of Nonlinear Dynamic Systems in Pharmacology using Chaos Synchronization and Grid Search", JPKPD

van Oordt, C. W. M. H et al. (2019), "ImmunoPET imaging to assess target engagement: Experience from ⁸⁹Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" J Nucl Med jnumed.118.214726 published ahead of print February 7, 2019

Norris, D. et al. (2018), Expansion Cohorts: Use in First-In-Human Clinical Trials To Expedite Development of Oncology,submitted to FDA, FDA-2018-D-2777-0001, DOI 10.17605/OSF.IO/NMGH8

Freedman, I. (2018), "Digital Health Standards", at FIS Global , November 27, 2018, Collegeville:PA

Freedman, I. (2018)  "Chaos Synchronization: Estimating Parameters of Noisy Complex Systems", in IEEE Section Night, October 20, 2018, Philadelphia:PA

Schieke, M. & Freedman, I. (2018), "Topological Mapping of Macroanatomy and Microanatomy for Use in Big Data and Augmented Intelligence Systems" i n IEEE-Standard Association Workshop on Digital Health Standards, September 11, 2018, Atlanta:GA

Pillai, N. et al. (2018), "Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: estimating tumor antigenicity in a model of immunotherapy," PBMB Special Issue Volume 139, November 2018, Pages 23-30

Pillai, N. et al. (2018), "Estimating parameters of chaotic systems: chaos synchronization combined with Nelder-Mead search, " in PAGE 2018: May 31, 2018, Montreux CH

O'Connor, M. A. et al. (2017), "Elucidating Exposure-Response (Safety and Efficacy) of Adct-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Containing Antibody Drug Conjugate, for Recommended Phase 2 Dose Determination in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma," in American Society of Hematology 59th Annual Meeting & Exposition, Atlanta GA Dec 9-12, 2017

Freedman, I., Bies, R. R., Pillai, N., Schwartz, S., Ho, T. (2017), "Estimating parameters of chaotic systems in pharmacology", invited talk in American Conference on Pharmacometrics 8, Oct 14-19, 2017, Ft. Lauderdale:FL

McGeoch, A.C. et al. (2017), "ImmunoPET imaging to assess target engagement: Experience from ⁸⁹Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" in Annual Congress of the European Association of Nuclear Medicine, Oct 21-25, 2017, Vienna:AT

"Pharmaco-Imaging in Translational Science and Research," in Pharmaco-Imaging in Drug and Biologics Development, (Brian R. Moyer, Narayan P. S. Cheruvu & Tom Hu, eds.), pub: AAPS/Springer

Nguyen, T-H-H. et al. (2016), Model evaluation of continuous data pharmacometric models: metrics and graphics, CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):87-109

Freedman, I., Bies, R. & Pillai, N. (2016), "Estimating parameters of chaotic systems," invited speaker, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, November 13-17, 2016, Denver:CO

Freedman, I. (2015), Imaging & Microdialysis: Complementary Modalities, invited panelist, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, October 24-29, 2015, Orlando:FL

Bies, R. R., Ho, T. & Freedman, I. (2015), Nonlinear dynamic physiological systems: Chaos Synchronization as an approach to parameter estimation n Kinetic and Dynamic Complexity in Drug Transit-Response in the Human Body, satellite meeting to Population Approach Group Europe 2015,  June 2, 2015, Hersonissos:GR

Freedman, I. (2015),Model Evaluation and Selection, invited talk to American Association of Pharmaceutical Sciences Pharmacometrics Focus Group, March 26, 2015

Freedman, I., Moyer, B.R & Cheruvu, N.P.S. (2014), Pharmaco-Imaging" in American Association of Pharmaceutical Sciences Translational Sciences 101 e-learning course, retrieved from http://www.aaps.org/TS101/

Freedman, I. (2014), Role of Pharmacology in Anti-Cancer Antibody Development,invited talk, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Nov 2-6, San Diego:CA

Austin, D., Freedman, I., Grove, R, Tolson, J. & Vanmeter, S. (2014), "The Relationship Between Peripheral B-Cell Levels and MRI Disease Activity in Relapsing-Remitting Multiple Sclerosis (RRMS)", dual presentation in American Academy of Neurology 66^th  Annual Meeting, Philadelphia:PA

Freedman, I. & Bies, R. (2013),"Chaos Synchronization," invited talk, in 3rd Annual Indiana Clinical and Translational Sciences Institute Symposium on Disease and Therapeutic Response Modeling, Nov 5-6, 2013, Indianapolis, IN

Freedman, I. (2013), Translational pharmacometric models of anti-cancer antibodies, invited talk, in 2^nd International Conference on Translational & Personalized Medicine, Aug 5-7, 2013, Chicago IL

Freedman, I. (2012), Case Studies in the Use of Imaging Agents in Proof-of-Concept and Early Proof-of-Efficacy Trials, invited talk, in National Biotechnology Conference, May 21-24, 2012, San Diego:CA

Freedman, I. (2012), Regulatory Opportunities and Hurdles with Imaging Agents in the Era of Personalized Medicine, invited panelist, in National Biotechnology Conference, May 21-24, 2012, San Diego:CA

Freedman, I. (2012),Translating Clinical and Pre-Clinical Information into Success", invited talk, in 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA

Freedman, I. (2012), Improving Integration of PK/PD Modeling into the Drug Development Process, invited panelist, in 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA

Freedman, I. (2011),The Impact of 3D Tissue Models on Drug Development and Predictive Safety, invited panelist, in Predictive Functional Tissue Models, November 17-18, 2011, Boston:MA

Freedman, I. (2011), Case Study Optimizing Design of a Phase 2 Clinical Trial in Relapsing-Remitting Multiple Sclerosis, invited talk, in Joint Statistical Meetings 2011, Miami FL July 30-August 4, 2011

Freedman, I. (2011), "Bridging from Western to East Asian Population in Accordance with ICH E5",in American Conference on Pharmacometrics 2011, San Diego CA April 3-6, 2011

Freedman, I et al. (2009), Bayesian Parametric Schild Analysis from a Whole Blood Stimulation Assay",in American Conference on Pharmacometrics 2009, Mystic CT October 4-7, 2009

Freedman, I. (2009),Feasibility of Immunogenicity Assessment based on Models of Polyclonal Anti-Drug Antibody Immunodynamics, in American Conference on Pharmacometrics 2009, Mystic CT October 4-7, 2009

History of Science

Freedman, I. (2023), The Intellectual Heritage of Babylonian Astronomy: Music of the Spheres," in The Intellectual Heritage of the Ancient Near East. Proceedings of the 64^th Rencontre Assyriologique Internationale and the 12^th Melammu Symposium, eds. Rollinger, R. et al., pubs. Austrian Academy of Sciences Press: Vienna Austria 2023. ISBN 978-3-7001-8574-1

Freedman. I. (2021), "Modern Methods of Chaos & Babylonian Mathematical Astronomy," Ronin Institute Public Seminar 

Freedman, I. (2021),  ^mul SAG.ME.GAR, NABU 2021-2 Nr. 52

Freedman, I.(2018), "The Intellectual Heritage of Babylonian Astronomy: Music of the Spheres," in Rencontre Assyriologique Internationale 64, July 14-20, 2018, Innsbruck Austria ; preprint DOI:10.13140/RG.2.2.36190.36161

Freedman, I.(2016), "Babylonian astronomers predicted lunar and planetary positions using iterated maps, forerunners of deterministic chaos," in Rencontre Assyriologique Internationale 62, July 11-15, 2016, Philadelphia PA

Cataloluk, O. & Freedman, I. (2016), "The meaning of armannu," in Rencontre Assyriologique Internationale 62, July 11-15, 2016, Philadelphia PA

Freedman, I. (2015), "On MA.NA EN.NUN in ^mulAPIN,"NABU 2015-2 Nr. 50

Freedman, I. (2015), Short Note: On an Assyriological Interpretation of the Book of Daniel 5:12-28, Journal of Translation 11(1), 74

Freedman, I. (2015), On an Assyriological interpretation of Constantine's labarum, retrieved from ResearchGate  DOI: 10.13140/RG.2.2.33956.76160

Freedman, I. (2015),The Marduk Star Nibiru, Cuneiform Digital Library Bulletin 2015:3, retrieved from https://cdli.ucla.edu/file/publications/cdlb2015_003.pdf

Freedman, I. (2014), On horses and bitumen in NABU 2014-1 Nr. 33